5 SIMPLE STATEMENTS ABOUT PKRRATING EXPLAINED

The interfacial residues are very conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations guidance a model in which activating RNA serves for a scaffold to bind several PKR monomers, expanding the

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